Skip to main content
Appalachian Today
News and events at Appalachian State University
  • For the media
  • COVID updates
  • Contact
  • Events
  • Webcams
  • Podcasts
  • In the Media
  • Grants
  • Speakers
  • All Posts
  • Topics
  • Accolades
  • Alumni
  • Arts and Humanities
  • Athletics
  • Awards and Honors
  • Community Engagement
  • Diversity
  • Events
  • Faculty and Staff
  • Gifts and Grants
  • Global
  • Health and Wellness
  • Publications
  • Research
  • Safety
  • Scholarships
  • Students
  • Sustainability
☰ Menu
  • Events
  • Webcams
  • Podcasts
  • In the Media
  • Grants
  • Speakers
  • All Posts
  • Topics
  • For the media
  • COVID updates
  • Contact

Reddish Lab awarded largest National Institutes of Health grant in App State’s history

Enzyme research by Dr. Michael Reddish, App State undergrads could lead to improved disease treatments

View larger image

Dr. Michael Reddish is an assistant professor in App State’s Department of Chemistry and Fermentation Sciences. The Reddish Lab focuses on studying human cytochrome P450 enzymes — proteins that are involved in the body’s metabolism of steroid hormones, pharmaceuticals, carcinogens and fat-soluble vitamins. Photo by Chase Reynolds

By Lauren Andersen
Edited by Anna Oakes
Posted Feb. 2, 2023 at 2:24 p.m.

BOONE, N.C. — A five-year, $1.6 million grant from the National Institutes of Health (NIH) — the largest NIH grant in Appalachian State University’s history — is the latest to support enzyme research led by Dr. Michael Reddish that could aid in the development of new and safer therapies, including those for cancer.

“Advancing knowledge, promoting discovery and applying research findings that benefit our region, state, nation and world are strategic priorities at App State, and our faculty and staff continue to set records for external funding,” said App State Provost Heather Hulburt Norris. “We are committed to cultivating undergraduate scholarship, and this record-setting grant will allow App State faculty and students to work side by side on research activities that have the very real potential to significantly improve health care.”

Reddish is an assistant professor in App State’s Department of Chemistry and Fermentation Sciences. The Reddish Lab focuses on studying human cytochrome P450 enzymes — proteins that are involved in the body’s metabolism of steroid hormones, pharmaceuticals, carcinogens and fat-soluble vitamins.

“Enzymes are components of our bodies that help make chemical reactions happen. We rely on these reactions to make the myriad of molecules (or chemicals) our bodies need to thrive,” explained Reddish. “Enzyme function can get altered from the optimal state due to genetics, exposure to things in our environment or age. In some cases, this altered function can lead to disease.”

The study of P450 enzymes has led to several important advances in medicine, including new therapies and the safer use of existing therapies. The $1,587,000 NIH grant, awarded by the agency’s National Institute of General Medical Sciences in one-year increments from September 2022 through June 2027, supports Reddish’s project “Structure-Function Studies of the Human Cytochrome P450 27 Family,” which focuses on the understudied 27 family of P450 enzymes.

According to Reddish, P450 27 enzymes catalyze the oxidations of several important hormones, including vitamin D derivatives, cholesterol derivatives and retinoids. The products of these reactions can have either positive or negative effects on human health, depending on their concentrations in the body, and therefore, it could be valuable to either increase or decrease these enzymes’ activities for clinical therapies.

“We are interested in learning more about the normal function of the P450 27 family of enzymes so that we can help suggest ways to fix the enzymes with medical therapies, such as pharmaceuticals, when their function gets disturbed,” Reddish said. “We are focused on the cytochrome P450 27 family because alterations in these enzymes have effects in hormone levels and can contribute to the development of some cancers.

“If we have a better understanding of the structure–function relationship, then we may be able to design pharmaceuticals to cause specific structural changes that lead to increased or decreased enzyme activity depending on a patient’s needs,” he added.

View larger image

Dr. Michael Reddish, center, is pictured with senior chemistry major Katie May, left, and App State alumnus Zach Davis ’22, a research technician in the Reddish Lab. Photo by Chase Reynolds

The NIH grant is among several awarded to Reddish and his team for his ongoing enzyme research at App State. Additional funding supporting this work includes:

  • A two-year, $249,840 grant from the National Science Foundation’s fund for Launching Early-Career Academic Pathways in the Mathematical and Physical Sciences was awarded to Reddish for his proposal “Determining All the Contributions of Adrenodoxin to Cytochrome P450 Catalysis,” beginning in August 2022. Adrenodoxin is a ferredoxin protein, which supplies electrons to cytochrome P450 enzymes. Resources from this grant are also being utilized to compensate undergraduate students involved in the research, to develop a new way to teach introductory chemistry that focuses on cohort-building, so that all students feel welcome in science, and to co-lead a course-based undergraduate research experience in the upper-level biochemistry lab at App State.
  • A grant from the North Carolina Biotechnology Center to study medications proposed to treat triple-negative breast cancers, which have “the least number of and least effective treatment options available,” Reddish said.
  • Multiple funding awards from App State’s Office of Student Research (OSR), including OSR Travel Grants to support student travel to conferences, OSR Research Grants to help with research supply costs for student research projects and OSR Undergraduate Research Assistantships to provide stipends for students active in research training.

Reddish’s research has been published in the Journal of Biological Chemistry and the Archives of Biochemistry and Biophysics, both peer-reviewed scientific journals.

View larger image

App State students from the Reddish Lab are pictured at the 2022 Southeast Enzyme Conference in Atlanta, where they presented posters. Pictured, from left to right, back row to front row, are senior chemistry major Katie May, from Waxhaw; Noah Arnold ’22, from Mount Pleasant; Hayden Campbell ’22, from Mooresville; Jackson Bartholomew-Schoch ’22, from Cornelius; and Ethan Harris ’22, from Clemmons. Photo submitted

View larger image

Mitch Donadieu ‘22, from Waxhaw, left, and Zach Davis ’22, from Asheville, present their poster at the 42nd Midwest Enzyme Chemistry Conference in Chicago in October 2022. Photo submitted

Undergraduates bring ‘fresh perspective’ to research

Much of the Reddish Lab’s work is performed by a group of undergraduate research students with interests in the sciences — providing high-level training in biochemistry research and instrumentation.

Reddish’s team is multidisciplinary, including seven undergraduate students studying chemistry, mathematical sciences and physics. He said his favorite part of working with students is their enthusiasm and curiosity.

“I also find they bring a fresh perspective to the research that helps me find flaws in my logic because they are less bogged down by ‘the way things are done.’ They ask great questions and help us find the best way to progress our research,” Reddish added.

Students in Reddish’s lab are encouraged to present at major conferences in the field, such as the Southeast Enzyme Conference and Midwest Enzyme Chemistry Conference. Equipped with research design and instrumentation skills, alumni of the Reddish Lab have gone on to pursue careers and doctoral degrees in chemistry and biology.

Zach Davis ‘22, who graduated in December 2022 and continues to work full time in the Reddish Lab, said that his work as a research technician “has taught me skills that are essential to lab work, and the research itself is very interesting.” Likewise, senior chemistry major Katie May said she is gaining more analytical chemistry experience and proficiency with the instruments used in her field.

Reddish incorporates his enzymology research in courses that include Biochemistry, Introductory Chemistry and Quantitative Analysis. Because his research is focused on learning more about how enzymes function in order to improve human health, Reddish’s research is of particular interest to students pursuing medical careers.

“I try to explain how the principles we teach in biochemistry courses are related to clinical therapies. I also try to explain the importance of the analytical chemistry techniques we teach students in studying how enzymes function,” Reddish said.

To learn more about Reddish’s lab, visit sites.google.com/appstate.edu/reddish-lab.

What do you think?

Share your feedback on this story.

Undergraduate students in App State’s Reddish Lab
  • Tanishka Dass, a sophomore chemistry major from Matthews.
  • Katie May, a senior chemistry major from Waxhaw.
  • Maya Palanza, a senior chemistry-biochemistry and physics-applied physics double major from Wilmington.
  • Katherine Provost, a junior chemistry major from Durham.
  • Lyndsay Snider, a senior mathematics major from Leesburg, Virginia.
  • Emma Stone, a junior chemistry major from Lexington.
  • Tai Vu, a junior chemistry major from Pineville.
App State team researches treatments for aggressive breast cancer
App State team researches treatments for aggressive breast cancer
Dec. 7, 2021

A research team at App State is investigating effective treatments for triple-negative breast cancer — the type of breast cancer with the least number of and least effective treatment options available.

Read the story
Department of Chemistry and Fermentation Sciences
Department of Chemistry and Fermentation Sciences

The A.R. Smith Department of Chemistry and Fermentation Sciences (CFS) offers a Bachelor of Arts in chemistry, a Bachelor of Science in chemistry with eight different concentrations and an interdisciplinary Bachelor of Science degree in fermentation sciences. The department’s programs prepare students to attend graduate and professional schools, as well as for employment in the pharmaceutical and fermentation industries and other business sectors.

Learn more

About the A.R. Smith Department of Chemistry and Fermentation Sciences

The A.R. Smith Department of Chemistry and Fermentation Sciences offers a Bachelor of Arts in chemistry, a Bachelor of Science in chemistry with eight different concentrations and an interdisciplinary Bachelor of Science degree in fermentation sciences. The department’s programs prepare students to attend graduate and professional schools, as well as for employment in the pharmaceutical and fermentation industries and other business sectors. Learn more at https://dcfs.appstate.edu.

About the College of Arts and Sciences

The College of Arts and Sciences (CAS) at Appalachian State University is home to 17 academic departments, two centers and one residential college. These units span the humanities and the social, mathematical and natural sciences. CAS aims to develop a distinctive identity built upon our university's strengths, traditions and unique location. The college’s values lie not only in service to the university and local community, but through inspiring, training, educating and sustaining the development of its students as global citizens. More than 6,400 student majors are enrolled in the college. As the college is also largely responsible for implementing App State’s general education curriculum, it is heavily involved in the education of all students at the university, including those pursuing majors in other colleges. Learn more at https://cas.appstate.edu.

About Appalachian State University

As the premier public undergraduate institution in the Southeast, Appalachian State University prepares students to lead purposeful lives as global citizens who understand and engage their responsibilities in creating a sustainable future for all. The Appalachian Experience promotes a spirit of inclusion that brings people together in inspiring ways to acquire and create knowledge, to grow holistically, to act with passion and determination, and to embrace diversity and difference. Located in the Blue Ridge Mountains, Appalachian is one of 17 campuses in the University of North Carolina System. Appalachian enrolls nearly 21,000 students, has a low student-to-faculty ratio and offers more than 150 undergraduate and graduate majors.

Undergraduate students in App State’s Reddish Lab
  • Tanishka Dass, a sophomore chemistry major from Matthews.
  • Katie May, a senior chemistry major from Waxhaw.
  • Maya Palanza, a senior chemistry-biochemistry and physics-applied physics double major from Wilmington.
  • Katherine Provost, a junior chemistry major from Durham.
  • Lyndsay Snider, a senior mathematics major from Leesburg, Virginia.
  • Emma Stone, a junior chemistry major from Lexington.
  • Tai Vu, a junior chemistry major from Pineville.
App State team researches treatments for aggressive breast cancer
App State team researches treatments for aggressive breast cancer
Dec. 7, 2021

A research team at App State is investigating effective treatments for triple-negative breast cancer — the type of breast cancer with the least number of and least effective treatment options available.

Read the story
Department of Chemistry and Fermentation Sciences
Department of Chemistry and Fermentation Sciences

The A.R. Smith Department of Chemistry and Fermentation Sciences (CFS) offers a Bachelor of Arts in chemistry, a Bachelor of Science in chemistry with eight different concentrations and an interdisciplinary Bachelor of Science degree in fermentation sciences. The department’s programs prepare students to attend graduate and professional schools, as well as for employment in the pharmaceutical and fermentation industries and other business sectors.

Learn more

Share

Topics

  • Faculty and Staff
  • Gifts and Grants
  • Health and Wellness
  • Research
  • Students

What do you think?

Share your feedback on this story.

Archives

Appalachian Today is an online publication of Appalachian State University. This website consolidates university news, feature stories, events, photo galleries, videos and podcasts.

The migration of materials from other sites is still incomplete, so if you cannot find what you're looking for here, please refer to the following sources:

  • Additional feature stories may be found at Appalachian Magazine
  • Podcasts may be found at Appalachian Magazine
  • Photo galleries and videos published prior to Jan. 1, 2015 may be found at Appalachian Magazine
  • A university-wide Google Calendar may be found at Events at Appalachian

Share

Topics

  • Faculty and Staff
  • Gifts and Grants
  • Health and Wellness
  • Research
  • Students

Other Recent Posts

  • Campus emergency siren test to be conducted <span style="white-space: nowrap;">April 5</span>
    Campus emergency siren test to be conducted April 5
  • Troy Johnson named vice chancellor of enrollment management at App State
    Troy Johnson named vice chancellor of enrollment management at App State
  • From waste to wear: App State alumna develops sustainable pigments for fashion, printing industries
    From waste to wear: App State alumna develops sustainable pigments for fashion, printing industries
  • <span style="color: #bc8801;">Appalachian Outdoorosity:</span> Dressing for the Cold (Part 2)
    Appalachian Outdoorosity: Dressing for the Cold (Part 2)
  • Appalachian Journal marks 50 years of spotlighting Appalachia
    Appalachian Journal marks 50 years of spotlighting Appalachia
  • Honoring women’s leadership and history at App State
    Honoring women’s leadership and history at App State
  • Lumbee tribal flag now hangs in App State’s student union, honoring the Lumbee people and their history
    Lumbee tribal flag now hangs in App State’s student union, honoring the Lumbee people and their history
  • Fact check: Mushrooms share more DNA with humans than plants [faculty featured]
    Fact check: Mushrooms share more DNA with humans than plants [faculty featured]
    USA Today
  • Since 1958, App State's Southern Appalachian plant collection has aided research, teaching and conservation
    Since 1958, App State's Southern Appalachian plant collection has aided research, teaching and conservation
  • <span style="color: #bc8801;">SoundAffect:</span> Daniel E. Dawes, JD on how to overcome deep-rooted challenges in the American health care system
    SoundAffect: Daniel E. Dawes, JD on how to overcome deep-rooted challenges in the American health care system
  • App State Office of Diversity brings monthly read-alouds to lab schools
    App State Office of Diversity brings monthly read-alouds to lab schools
  • 5 award-winning authors to visit App State for spring 2023 Hughlene Bostian Frank Visiting Writers Series
    5 award-winning authors to visit App State for spring 2023 Hughlene Bostian Frank Visiting Writers Series

Archives

Appalachian Today is an online publication of Appalachian State University. This website consolidates university news, feature stories, events, photo galleries, videos and podcasts.

The migration of materials from other sites is still incomplete, so if you cannot find what you're looking for here, please refer to the following sources:

  • Additional feature stories may be found at Appalachian Magazine
  • Podcasts may be found at Appalachian Magazine
  • Photo galleries and videos published prior to Jan. 1, 2015 may be found at Appalachian Magazine
  • A university-wide Google Calendar may be found at Events at Appalachian
  • Events
  • Videos
  • Galleries
  • In the Media
  • Grants
  • Speakers
  • All Posts
  • Topics
  • For the media
  • COVID updates
  • Contact

App State

Copyright 2023 Appalachian State University. All rights reserved.

University Communications
ASU Box 32153
Boone, NC 28608
828-262-6156
ucomm@appstate.edu

Abouts

Disclaimer | EO Policy | Accessibility | Website manager: montaldipa (beltmr) .. | Website Feedback

Facebook Twitter YouTube Instagram LinkedIn Snapchat